SARS-CoV-2 Variants: An Emerging Landscape of Therapeutic Targets

As SARS-CoV-2 variants have emerged the CDC has systematically classified them as variants of interest, variants of concern (VOC), and variants of high concern.1 Three independent SARS-CoV-2 VOCs have emerged in the UK (B.1.1.7), South Africa (B.1.351), and Brazil (P.1) (Table 1). The rapid dominance of these variants within their…

IgA Antibody Detection in COVID-19

IgA Antibody Detection in COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19) which was first reported in Wuhan, China in December 2019 [1]. Currently, the United States has become one of the most impacted regions with confirmed cases totaling more than 5.6 million and with more than 175,000 deaths [2]. The…

Cell-Based Therapy for COVID-19: A Secretome to Calm the Storm

Cell-Based Therapy for COVID-19: A Secretome to Calm the Storm

In COVID-19 cases of greatest severity, a defective host immune response appears to play a central role. In particular, the acute respiratory distress syndrome (ARDS) and organ failure that typify a severe disease course are accompanied by elevated levels of IL-2, IL-7, G-CSF, IFN-γ, IP-10, MCP-1, MIP1-α, and TNF-α [1].…

COVID-19 Research Tools 101

COVID-19 Research Tools 101

Introduction The coronavirus disease 2019 (COVID-19) is caused by the highly contagious SARS-CoV-2 virus. [1] Some infected individuals are asymptomatic while others experience very severe symptoms that can result in death (Figure 1). [2] More specifically, those over 55 years old or have underlying conditions are especially vulnerable to developing…