High-Density Screening Arrays Can Help You Focus Your Research Efforts

High-Density Screening Arrays Can Help You Focus Your Research Efforts

Autophagy has been shown to play a critical role in kidney maintenance, disease, and aging. In this study, the authors identified a novel mechanism by which IFN-γ activates autophagy in human kidney epithelial cells. They found that IFN-γ promoted tryptophan depletion, activated the eIF2α kinase general control nonderepressible-2 (GCN2), and…

Assessing Protein Panels Can Indicate How They Work Within Networks To Control Complex Processes

Assessing Protein Panels Can Indicate How They Work Within Networks To Control Complex Processes

The aim of this study was to characterize cellular processes that are altered in mammary endothelial cells (MECs) displaying reduced cyclin D1 activity in an effort to better understand the biological effects of pharmacological approaches to treat breast cancer. The use of an antibody array was instrumental in determining that…