Exosomes: A Source of Protein Biomarkers

Exosomes are 30-150 nm extracellular vesicles that are endocytically released from cells. Exosomes were previously thought to simply exude unnecessary proteins from cells; however, more recent research has highlighted their importance in cell-to-cell communication by transporting biomolecules such as mRNA, microRNA, and protein through the circulatory system. Recipient cells may…

Aptamer Selection & Development

Aptamer Selection & Development

What are Aptamers? Often described as synthetic antibodies, aptamers are single-stranded DNA or RNA molecules that fold into secondary structures which can bind to target molecules with high affinity and specificity. In 1990, the first aptamer was developed against T4 DNA Polymerase using RNA1. Since then, both aptamer selection methods…