Skip to navigationSkip to contentSkip to footer
  • Home
  • Applications
  • Infectious Disease & Vaccines
  • COVID-19
  • COVID-19 Proteins

COVID-19 Proteins

The SARS-CoV-2 virus, which is responsible for COVID-19, comprises nearly 30 proteins, including the Spike and Nucleocapsid proteins. RayBiotech offers a comprehensive catalog of recombinant SARS-CoV-2 proteins for all domains and variants of the COVID-19 virus. Other recombinant coronavirus proteins, including SARS-CoV, MERS-CoV, and HCoV-HKU1, are also available for purchase.

Browse All COVID-19 Proteins
SARS-CoV-2_Proteins

Features

The recombinant SARS-CoV-2 proteins recommended applications include ELISA, western blotting, lateral flow, antibody generation, vaccine development, and more. All recombinant proteins have a purity greater than 90% determined by SDS-PAGE under reducing conditions and visualized by Coomassie blue staining. Images are available on the product-specific pages. Multiple expression systems are available, including Human Embryonic Kidney 293 (HEK293) Cells and E.coli.

Learn about the roles SARS-CoV-2 proteins and endogenous proteins play in COVID-19 infection in our post “COVID-19 Biology 101”.

Types of COVID-19 Proteins

Spike Protein

The spike protein (S-protein) is a structural, transmembrane protein that is displayed on the surface of the viral particle.

Spike Protein Variants

SARS-CoV-2 variants have mutations within the gene encoding for the Spike (S) protein, which facilitates viral entry by binding to host receptors.

Nucleocapsid Protein

The nucleocapsid protein (N-protein) is a structural protein that binds to the coronavirus RNA genome.

Membrane Protein

The membrane protein (M-protein) is the most abundant structural protein of SARS-CoV-2.

Other Coronavirus Proteins

Recombinant SARS, MERS, and HKU1 coronavirus proteins.

Thrombosis Proteins

Inflammation associated with COVID-19 can lead to a type of thrombosis called "disseminated intravascular coagulopathy" (DIC).

Host Receptors

ACE2 is an endogenous receptor that is required for SARS-CoV-2 viral entry. Other host receptors, NRP1, AXL, CD147, GRP-78 also assist.

Browse All COVID-19 (SARS-CoV-2) Proteins

Nucleocapsid (N) Proteins:



Spike Subunit 1 (S1) Proteins:


Spike Subunit 2 (S2) Proteins:



Membrane Proteins:


Variant Proteins:



Other SARS Proteins:


S1 RBD Binding Proteins:



Thrombosis-related Proteins:

viral-particle

FEATURED SERVICE

COVID-19 Pseudovirus Service

View Pseudovirus Services

Related Services

Protein Expression and Purification

Comprehensive custom protein service covers every step of production, from gene cloning through protein purification. We can also perform downstream processing like protein desalting, lyophilization, vialing, and labeling.

COVID-19 Antibodies

RayBiotech offers monoclonal and polyclonal antibodies against SARS-CoV-2 (COVID-19) proteins, including the Nucleocapsid protein (N-protein) and multiple domains and variants of the Spike protein (S-protein).

COVID-19 ELISAs

Current testing for the SARS-CoV-2 virus is limited, and compared to RT-qPCR, ELISA is a less complex procedure that uses more affordable and available equipment.

What customers are saying

Quote icon

Research Scientist

University of California, Davis

Quote icon

Research Scientist

University of California, Davis

It works well for fluorescent labeling and confocal microscopy.

We employed this protein for site-specific glycosylation analysis. It works great.

Catalog #

Protein Domain

Expression Region

Expression Host

Tag

230-30164

Full length

Met1 - Ala419

HEK293 Cell

C-His

230-01104

Full length

Met1 - Ala419

E.coli

N-His

Catalog #

Protein Domain

Expression Region

Expression Host

Tag

230-30162

RBD

Arg319 - Phe541

HEK293 Cell

C-His

230-30166

RBD

Arg319 - Phe541

HEK293 Cell

C-Fc

230-01102

RBD

Arg319 - Phe541

E.coli

N-His

230-01101

Full length

Val16 - Gln690

E.coli

N-His

230-30191

N-terminal

Val16-Phe318

HEK293 Cell

C-His

230-30214

N-terminal

Val16-Phe318

HEK293 Cell

C-Fc

Catalog #

Protein Domain

Expression Region

Expression Host

Tag

230-01103

Full length

Met697 - Pro1213

E.coli

N-His

230-30179

C-terminal CendR domain

Asn542-Arg685

HEK293 Cell

N-His

230-30180

C-terminal CendR domain

Asn542-Arg685

HEK293 Cell

C-Fc

Catalog #

Protein Domain

Expression Region

Expression Host

Tag

230-01124

Glycoprotein, C-terminal

Arg101-Gln222

E.coli

N-His

Catalog #

Protein
Domain

Subvariant

Mutations

Expression
Host

Tag

230-30157

S1 RBD

N331Q

HEK293 cell

C-His

230-30184

S1 RBD

Alpha B.1.1.7 (U.K.), Beta B.1.351 (South Africa) Gamma P.1 (Brazil).

N501Y

HEK293 cell

C-His

230-30185

S1 RBD

Alpha B.1.1.7 (U.K.), Denmark Mink Variant

Y453F

HEK293 cell

C-His

230-30186

S1 RBD

Alpha B.1.1.7 (U.K.), Beta B.1.351 (South Africa)

D614G

HEK293 cell

C-His

230-30187

S1 RBD

Alpha B.1.1.7 (U.K.)

N439K

HEK293 cell

C-His

230-30188

S1 RBD

Beta B.1.351 (South Africa), Gamma P.1 (Brazil)

E484K

HEK293 cell

C-His

230-30196

S1 RBD

Delta B.1.617.2 (India)

L452R/E484Q

HEK293 cell

C-His

230-30197

S1 RBD

Delta B.1.617.2 (India)

L452R

HEK293 cell

C-His

230-30198

S1 RBD

Delta B.1.617.2 (India)

E484Q

HEK293 cell

C-His

230-30203

S1 RBD

Delta B.1.617.2 (India)

T478K

HEK293 cell

C-His

230-30208

S1 RBD

Delta B.1.617.2 (India)

L452R/T478K

HEK293 cell

C-His

230-30209

S1 subunit,
full length

Delta B.1.617.2 (India)

S1F, Y145H

HEK293 cell

C-His

230-30210

S1 subunit,
full length

Delta B.1.617.2 (India)

S1F, A222V

HEK293 cell

C-His

230-30211

S1 subunit,
full length

Delta B.1.617.2 (India)

S1F, Y145H/A222V

HEK293 cell

C-His

230-30206

S1 RBD

Lambda C.37 (Peru)

L452Q

HEK293 cell

C-His

230-30207

S1 RBD

Lambda C.37 (Peru)

F490S

HEK293 cell

C-His

230-30202

S1 RBD

Lambda C.37 (Peru)

L452Q/F490S

HEK293 cell

C-His

230-30212

S1 RBD

Mu B.1.621 (Colombia)

R346K

HEK293 cell

C-His

230-30213

S1 RBD

Mu B.1.621 (Colombia)

R346K/E484K/N501Y

HEK293 cell

C-His

230-30201

S1 RBD

Omicron B.1.1.529 (South Africa)

G339D, S371L, S373P, S375F, K417N, N440K,
G446S, S477N, T478K, E484A, Q493R, G496S,
Q498R, N501Y, Y505H

HEK293 cell

C-His

230-30218

Nucleocapsid
Protein

Omicron B.1.1.529 (South Africa)

P13L, E31del, R32del, S33del, R203K, G204R

HEK293 cell

C-His

230-30018

S1 RBD

Omicron B.1.1.529 BA.2

G339D, S371F, S373P, S375F, T376A, D405N, R408S,
K417N, N440K, S477N, T478K, E484A, Q493R,
Q498R, N501Y, Y505H

HEK293 cell

C-His

230-30244

S1 RBD

Omicron BA.4

G339D, S371F, S373P, S375F, T376A,
D405N, R408S, K417N, N440K, L452R,
S477N, T478K, E484A, F486V, Q498R,
N501Y, Y505H

HEK293 cell

C-His

230-30245

S1 RBD

Omicron BA.5

G339D, S371F, S373P, S375F, T376A,
D405N, K417N, N440K, L452R, S477N,
T478K, E484A, F486V, Q498R, N501Y,
Y505H

HEK293 cell

C-His

230-30246

S1 RBD

Omicron BA.2.75.2

G339H, R346T, S371F, S373P, S375F,
T376A, D405N, R408S, K417N, N440K,
G446S, N460K, S477N, T478K, E484A,
F486S, Q498R, N501Y, Y505H

HEK293 cell

C-His

230-30247

S1 RBD

Omicron XBB.1

G339H, R346T, L368I, S371F, S373P, S375F,
T376A, D405N, R408S, K417N, N440K, V445P,
G446S, N460K, S477N, T478K, E484A, F486S,
F490S, Q498R, N501Y, Y505H

HEK293 cell

C-His

230-30248

S1 RBD

Omicron BQ1.1

G339H, R346T, S371F, S373P, S375F, T376A,
D405N, R408S, K417N, N440K, K444T, L452R,
N460K, S477N, T478K, E484A, F486V, Q498R,
N501Y, Y505H

HEK293 cell

C-His

Catalog #

Species

Target

Expression Host

Tag

230-30192

SARS CoV

S1, full length

HEK293 Cell

C-His

230-30193

SARS CoV

S1, RBD

HEK293 Cell

C-His

230-30194

SARS CoV

Nucleocapsid Protein

HEK293 Cell

C-His

230-30195

MERS CoV

S1, full length

HEK293 Cell

C-His

230-30204

MERS CoV

S1, RBD

HEK293 Cell

C-His

230-30205

MERS CoV

Nucleocapsid Protein

HEK293 Cell

C-His

230-30199

HCov-HKU1

S1, full length

HEK293 Cell

C-His

230-30200

HCov-HKU1

S1, RBD

HEK293 Cell

C-His

Catalog #

Species

Target

Accesion #

Expressed Region

Expression Host

Tag

230-30165

Human

ACE2

Q9BYF1

Gln18 - Ser740

HEK293 Cell

C-His

230-30177

Mouse

ACE2

Q8R0I0

Gln18-Thr740

HEK293 Cell

C-His

230-30176

Human

NRP1, isoform 2

O14786-2

Phe22-Lys644

HEK293 Cell

C-His

230-30178

Human

NRP1, isoform 1

O14786-1

Phe22-Pro856

HEK293 Cell

C-His

230-30189

Human

NRP1, isoform 1
mutant (S346A, E348A, T349A)

O14786-1

Phe22-Pro856

HEK293 Cell

C-His

230-30100

Human

GRP-78

P11021

Glu19-Leu654

HEK293 Cell

C-His

230-30181

Human

BASIGIN, BSG

P35613-2

Thr28-Leu206

HEK293 Cell

C-His

230-30190

Human

AXL

P30530

Ala26-Trp451

HEK293 Cell

C-His

Catalog #

Species

Target

Accesion #

Expressed Region

Expression Host

Tag

230-30170

Coagulation factor II (F2), Thrombin

Human

HEK293 Cell

P00734

Full length

N-His

230-30063

SERPINE1

Mouse

HEK293 Cell

Q7TPE9

Full length

N-His

230-30042

SERPINE1

Mouse

HEK293 Cell

P97298

Full length

N-His

230-30171

Serpin F2

Human

HEK293 Cell

P08697

Asn40-Lys491

N-His

RayBiotech's COVID-19 pseudovirus service enables the study of the SARS-CoV-2 virus in cell culture. This service is ideal for screening patient serum for neutralizing antibodies, validating inhibitors of the Spike-ACE2 interaction, and COVID-19 vaccine development.

Products
  • Multiplex Assays
  • ELISA Kits
  • Proteins and Peptides
  • Antibodies
  • Flow Cytometry
  • Assay Kits
  • Molecular Biology

Sign up to get promotions on your favorite research tools and research updates.

Sign up to Newsletter (opens in new tab)
Services
  • Multiplex Assay Services
  • ELISA Services
  • Antibody Services
  • Custom Protein Services
  • CRO Services
  • Flow Cytometry Services
  • Simoa – Single Molecule Array Services
Resources
  • Manual Protocols
  • Resource Library
©2007-2026 RayBiotech, Inc. All rights reserved.Life Science Web Design By Supreme
  • Privacy Policy
  • Terms & Conditions
  • ISO Certification
  • Risk Free Guarantee
  • Promotions
  • Learning Center
  • Array Analysis Tools
  • Publications / Citations
  • Publications by RayBiotech Scientists
    • About Us
    • About RayBiotech
    • Careers
    • Quality Systems
    • Business Partnerships
    • News & Events
    • Reducing Our Emissions
    Contact Us
    • Contacts
    • Distributors
    • Certified Service Providers
    ISO 13485:2016cGMP
    ISO 17025:2017CLIA
    Need Help?770-729-2992
    MY ACCOUNT

    Your cart is empty.

    RayBiotech
    RayBiotech
    • Products
      • Multiplex Assays
      • ELISA Kits
      • Proteins
      • Antibodies
      • Flow Cytometry
      • Assay Kits
      • Molecular Biology
      • Other Products
      • Human Cytokine Array C5
      • Human IL-6 ELISA
      • Human Inflammation Array Q3
      • Mouse Cytokine Array C3
      • Recombinant SARS-CoV-2 Spike Protein, S1 Subunit
      • Human Phosphorylation Pathway Profiling Array C55
      • Antibody Arrays
      • Proteome Profiling Arrays
      • Cytometric Bead Arrays
      • Epitope Mapping Peptide Arrays
      • Protein Arrays
      • PTM Multiplex Assays
      • NexaTag® Ultrasensitive Multiplex ELISA
      • Sandwich ELISA
      • Competitive ELISA
      • PTM ELISA
      • NexaTag® Ultrasensitive qIPCR ELISA
      • Indirect ELISA
      • Bridging ELISA
      • Cell-Based ELISA
      • Recombinant Proteins
      • GMP Proteins
      • Native Proteins
      • Peptides
      • Primary Antibodies
      • Secondary Antibodies
      • Flow Cytometry Antibodies
      • Isotype Controls
      • Antibody Pairs
      • Flow Cytometry Antibodies
      • Flow Cytometry Reagents
      • Flow Cytometry Assays
      • Cytometric Bead Arrays
      • Fluorescent Beads
      • Quantum Dots
      • Metabolism Assays
      • Ligand Binding Assays
      • Drug Antibody (DA) & ADA Assays
      • Transcription Factor Activity Assays
      • PCR Assays
      • Nucleic Acid Assays
      • Epigenetics
      • Mitochondrial Assays
      • Reagents
      • Cell Culture
      • Biospecimen Samples
      • Sample Collection & Preparation
      • Lysates
      • Magnetic Beads
      • Lab Equipment and Supplies
      • Biological Buffers

      Featured Products

      Human Cytokine Array C5Human IL-6 ELISAHuman Inflammation Array Q3Mouse Cytokine Array C3Recombinant SARS-CoV-2 Spike Protein, S1 SubunitHuman Phosphorylation Pathway Profiling Array C55
    • Services
      • Multiplex Assay Services
      • ELISA Services
      • Protein Services
      • Antibody Services
      • CRO Services
      • Flow Cytometry Services
      • SIMOA – Single Molecule Array
      • Other Services
      • Proteomic Services
      • Custom Arrays
      • Array Scanning and Analysis
      • Custom Protein Production
      • GMP Protein Production
      • IHC Controls
      • Stable Cell Line Development
      • Molecular Biology Services
      • Antibody Production
      • Recombinant Antibody Expression
      • Bulk Antibody Production
      • Antibody Conjugation Services
      • Cell Biology Services
      • Epitope Mapping Services
      • Biomarker Discovery
      • Cell Biology Services
      • Antibody Drug Development & Characterization
      • Pharmacokinetic and Pharmacodynamic Analysis
      • Assay Development Services
      • Molecular Biology Services
      • Multiomics Services
      • Diagnostic Assay Development
      • GMP Protein Production
      • Biostatistics and Bioinformatics
      • Bulk Antibody Production
      • QC Testing Services
      • Auto-Western Blot Service
      • COVID-19 Pseudovirus Service
      • Biospecimen Samples & Sample Services
      • RNA & DNA Methylation Detection Services
    • Research Areas
      • Cell Signaling Pathways
      • Areas of Interest
      • Akt Signaling Pathway
      • AMPK Signaling pathway
      • ErbB Signaling Pathway
      • Hedgehog Signaling Pathway
      • HIF1-alpha Signaling Pathway
      • IGFR1 Signaling Pathway
      • JAK-STAT Signaling Pathway
      • MAPK Signaling Pathway
      • mTOR Signaling Pathway
      • NF-kappaB Signaling Pathway
      • Notch Signaling Pathway
      • p53 Signaling Pathway
      • PKC Pathway
      • TGF-beta Signaling Pathway
      • Wnt/beta-Catenin Pathway
      • Antibody Drug Development
      • Autoimmunity & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Infectious Disease & Vaccines
      • Neuroscience
      • Obesity
      • Post Translational Modifications
      • RNA & DNA Modifications
    • Resources
      • Array Picker Tool
      • Sample Shipment Instructions
      • Sample Preparation Tips
      • Publications / Citations
      • Promotions
      • Resource Library
      • Learning Center
      • Manual Protocols
      • Array Analysis Tools
    • Contact Us
      • Distributors & Service Providers
    • About Us
      • Quality Systems
      • Business Partnerships
      • Careers
      • News & Events